Epidermal RORα Maintains Barrier Integrity and Prevents Allergic Inflammation by Regulating Late Differentiation and Lipid Metabolism.

ABSTRACT: The skin epidermis provides a barrier that is imperative for preventing transepidermal water loss (TEWL) and protecting against environmental stimuli. The underlying molecular mechanisms for regulating barrier functions and sustaining its integrity remain unclear. RORα is a nuclear receptor highly expressed in the epidermis of normal skin. Clinical studies showed that the epidermal RORα expression is significantly reduced in the lesions of multiple inflammatory skin diseases. In this study, we investigate the central roles of RORα in stabilizing skin barrier function using mice with an epidermis-specific Rora gene deletion (Rora^EKO). While lacking spontaneous skin lesions or dermatitis, Rora^EKO mice exhibited an elevated TEWL rate and skin charact

SUBMITTER: Hua X 

PROVIDER: S-EPMC11476758 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature