Study of impacts of two types of cellular aging on the yeast bud morphogenesis.

ABSTRACT: Understanding the mechanisms of the cellular aging processes is crucial for attempting to extend organismal lifespan and for studying age-related degenerative diseases. Yeast cells divide through budding, providing a classical biological model for studying cellular aging. With their powerful genetics, relatively short cell cycle, and well-established signaling pathways also found in animals, yeast cells offer valuable insights into the aging process. Recent experiments suggested the existence of two aging modes in yeast characterized by nucleolar and mitochondrial declines, respectively. By analyzing experimental data, this study shows that cells evolving into those two aging modes behave differently when they are young. While buds grow linearly in both modes, cells that consistently gener

SUBMITTER: Tsai K 

PROVIDER: S-EPMC11476777 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature