Investigating the Causal Effects of Exercise-Induced Genes on Sarcopenia.

ABSTRACT: Exercise is increasingly recognized as an effective strategy to counteract skeletal muscle aging and conditions such as sarcopenia. However, the specific exercise-induced genes responsible for these protective effects remain unclear. To address this, we conducted an eight-week aerobic exercise regimen on late-middle-aged mice and developed an integrated approach that combines mouse exercise-induced genes with human GWAS datasets to identify causal genes for sarcopenia. This approach led to significant improvements in the skeletal muscle phenotype of the mice and the identification of exercise-induced genes and miRNAs. By constructing a miRNA regulatory network enriched with transcription factors and GWAS signals related to muscle function and traits, we focused on 896 exercise-induced gene

SUBMITTER: Wang L 

PROVIDER: S-EPMC11476887 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature