A systematic review of sample size estimation accuracy on power in malaria cluster randomised trials measuring epidemiological outcomes.

ABSTRACT:

Introduction

Cluster randomised trials (CRTs) are the gold standard for measuring the community-wide impacts of malaria control tools. CRTs rely on well-defined sample size estimations to detect statistically significant effects of trialled interventions, however these are often predicted poorly by triallists. Here, we review the accuracy of predicted parameters used in sample size calculations for malaria CRTs with epidemiological outcomes.

Methods

We searched for published malaria CRTs using four online databases in March 2022. Eligible trials included those with malaria-specific epidemiological outcomes which randomised at least six geographical clusters to study arms. Predicted and observed sample size parameters were extracted by reviewers for each trial. Pair-wise Spea

SUBMITTER: Biggs J 

PROVIDER: S-EPMC11476958 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature