Bovine Neutrophil β-Defensin-5 Provides Protection against Multidrug-Resistant <i>Klebsiella pneumoniae</i> via Regulating Pulmonary Inflammatory Response and Metabolic Response.

ABSTRACT: Klebsiella pneumoniae (K. pneumoniae), a kind of zoonotic bacteria, is among the most common antibiotic-resistant pathogens, and it causes nosocomial infections that pose a threat to public health. In this study, the roles of synthetic bovine neutrophil β-defensin-5 (B5) in regulating inflammatory response and metabolic response against multidrug-resistant K. pneumoniae infection in a mouse model were investigated. Mice were administrated intranasally with 20 μg of B5 twice and challenged with K. pneumoniae three days after B5 pretreatment. Results showed that B5 failed to directly kill K. pneumoniae in vitro, but it provided effective protection against multidrug-resistant K. pneumoniae via decreasing the bacterial load in the lungs and spleen, an

SUBMITTER: Zhu S 

PROVIDER: S-EPMC11477005 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature