GPX5-Enriched Exosomes Improve Sperm Quality and Fertilization Ability.

ABSTRACT: Semen preservation quality affects the artificial insemination success rate, and seminal exosomes are rich in various proteins that are transferable to sperm and conducive to sperm-function preservation during storage. However, the specific effects of these proteins remain unclear. In this study, the specific effects of these proteins on semen preservation quality and fertilization capacity were investigated through a proteomic analysis of seminal exosomes from boars with high conception rates (HCRs) and low conception rates (LCRs). The results revealed significant differences in the expression of 161 proteins between the two groups, with the GPX5 level being significantly higher in the HCR group (p < 0.05). The role of GPX5 was further investigated by constructing engineered exosom

SUBMITTER: Huang J 

PROVIDER: S-EPMC11477019 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature