Hair Growth-Promoting Effect of <i>Hydrangea serrata</i> (Thunb.) Ser. Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study.

ABSTRACT: With the escalating prevalence of hair loss, the demand for effective hair loss treatment has surged. This study evaluated the effects of hot water extract of Hydrangea serrata (Thunb.) Ser. leaf (WHS) on hair growth, employing cell cultures, mice, and human skin organoid models. Both WHS and hydrangenol were found to enhance 5α-reductase inhibitory activity. WHS and hydrangenol have been shown to stimulate dermal papilla cell (DPC) growth, potentially through factors like keratinocyte growth factor (KGF), fibroblast growth factor 10 (FGF10), and transforming growth factor-β1 (TGF-β1). They also elevated the expression levels of keratin genes (K31 and K85) and the ceramide synthase (CerS3) gene, crucial clinical indicators of hair health. Fu

SUBMITTER: Park S 

PROVIDER: S-EPMC11477035 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature