Real-World Efficacy of Biological Therapies in Severe Asthma: A Focus on Small Airways.

ABSTRACT: Background: Severe asthma is a challenging condition that often resists traditional treatments and requires high-dose inhaled corticosteroids and other controllers to manage uncontrolled symptoms. Recent advances include the use of biologic agents targeting specific inflammation pathways, which have improved symptom control and quality of life, although their effects on small airways remain less understood. Methods: This prospective observational study, conducted at Tor Vergata University Hospital in Rome from July 2021 to March 2024, aims to evaluate the efficacy of treatments in patients with uncontrolled severe asthma. It involves baseline assessments and follow-ups at 1 and 3 months post-biological therapy initiation, focusing on both spirometric and non-spirometric (osci

SUBMITTER: Ora J 

PROVIDER: S-EPMC11477072 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature