Biallelic Loss of 7q34 (<i>TRB</i>) and 9p21.3 (<i>CDKN2A</i>/<i>2B</i>) in Adult Ph-Negative Acute T-Lymphoblastic Leukemia.

ABSTRACT: Tumor cells of acute lymphoblastic leukemia (ALL) may have various genetic abnormalities. Some of them lead to a complete loss of certain genes. Our aim was to reveal biallelic deletions of genes in Ph-negative T-ALL. Chromosomal microarray analysis (CMA) was performed for 47 patients with de novo Ph-negative T-ALL, who received treatment according to RALL-2016m clinical protocol at the National Medical Research Center for Hematology (Moscow, Russia) from 2017 to 2023. Out of forty-seven patients, only three had normal molecular karyotype. The other 44 patients had multiple gains, losses, and copy neutral losses of heterozygosity. Biallelic losses were found in 14 patients (30%). In ten patients (21%), a biallelic deletion of 9p21.3 involved a different number of genes, however CDKN2A</

SUBMITTER: Risinskaya N 

PROVIDER: S-EPMC11477120 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature