PD-L1⁺ Lymphocytes Are Associated with CD4⁺, Foxp3⁺CD4⁺, IL17⁺CD4⁺ T Cells and Subtypes of Macrophages in Resected Early-Stage Non-Small Cell Lung Cancer.

ABSTRACT: The non-canonical PD-L1 pathway revealed that programmed-death ligand 1 (PD-L1) expression in immune cells also plays a crucial role in immune response. Moreover, immune cell distribution in a tumour microenvironment (TME) is pivotal for tumour genesis. However, the results remain controversial and further research is needed. Distribution of PD-L1-positive (PD-L1⁺) tumour-infiltrating lymphocytes in the context of TME was assessed in 72 archival I-III stage surgically resected NSCLC tumour specimens. Predominant PD-L1⁺ lymphocyte distribution in the tumour stroma, compared to islets, was found (p = 0.01). Higher PD-L1⁺ lymphocyte infiltration was detected in smokers due to their predominance in the stroma. High PD-L1⁺ lymphocyte infiltrati

SUBMITTER: Gureviciene G 

PROVIDER: S-EPMC11477418 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature