Epimesatines P-S: Four Undescribed Flavonoids from <i>Epimedium sagittatum</i> Maxim. and Their Cytotoxicity Activities.

ABSTRACT: In this study, four previously undescribed flavonoids, named epimesatines P (1), Q (2), R (3), and S (4), were isolated from the aerial parts of Epimedium sagittatum Maxim. Their structures and absolute configurations were confirmed via spectroscopic analyses, quantum chemical electronic circular dichroism (ECD) calculations, Mo₂(OAc)₄-induced ECD, and Rh₂(OCOCF₃)₄-induced ECD experiments. Epimesatines Q and R were characterized by the presence of furan rings. A cytotoxicity assay demonstrated that epimesatines P-S exhibited significant inhibitory effects on the viability of MCF-7 human breast cancer cells, with IC₅₀ values ranging from 1.27 to 50.3 μM. Notably, epimesatines Q and R exhibit

SUBMITTER: Xie SS 

PROVIDER: S-EPMC11477557 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature