Updated Risk Assessment of Cannabidiol in Foods Based on Benchmark Dose-Response Modeling.

ABSTRACT: Cannabidiol (CBD), a non-psychotropic main component of the Cannabis plant, has been approved as a drug in the European Union (EU) under the name "Epidyolex". However, its approval process as a food ingredient under the Novel Food Regulation was paused by the European Food Safety Authority (EFSA) due to a lack of safety data. Nevertheless, there is a growing, unregulated market in which CBD is advertised with various health claims and dosage instructions. Of particular concern is its toxic effect on the liver and possible reproductive toxicity in humans. Studies suitable for calculating the benchmark dose were identified from the available data. Animal studies yielded a benchmark dose lower confidence limit (BMDL) of 43 mg/kg bw/day, which translates into a safe human dose of approx

SUBMITTER: Wisotzki E 

PROVIDER: S-EPMC11477611 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature