The Zeb1-Cxcl1 axis impairs the antitumor immune response by inducing M2 macrophage polarization in breast cancer.

ABSTRACT: Zeb1, a key epithelial-mesenchymal transition (EMT) regulator, has recently been found to be involved in M2 macrophage polarization in the tumor immune microenvironment, thereby promoting tumor development. However, the underlying mechanism of Zeb1-induced M2 macrophage polarization remains largely unexplored. To identify the potential role of Zeb1 in remodeling the tumor immune microenvironment in breast cancer, we crossed the floxed Zeb1 allele homozygously into PyMT mice to generate PyMT;Zeb1^cKO (MMTV-Cre;PyMT;Zeb1^fl/fl ) mice. We found that the recruitment of M2-type tumor-associated macrophages (TAMs) was significantly reduced in tumors from PyMT;Zeb1^cKO mice, and their tumor suppressive effects were weakened. Mechanistically, Zeb1

SUBMITTER: Ou Y 

PROVIDER: S-EPMC11477816 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature