Attenuation of aggressive tumor progression of anaplastic thyroid cancer by p53.

ABSTRACT: Anaplastic thyroid cancer (ATC) is the most aggressive thyroid cancer, with very limited treatment options. Mutations of p53 are associated with lethal outcomes of ATC. In this study, we tested the hypothesis that wild type p53 (WTp53) mitigates its aggressive progression. We used human 8505C cells (from human ATC tumors) as a model, harboring a BRAF^V600E mutation and single of mutated p53^C742G allele. We exogenously expressed WTp53 or mutant p53^C742G into 8505C cells (8505C-WTp53 or 8505C-MTp53, respectively). The expressed WTp53 inhibited cell proliferation, decreased cell migration, and induced apoptosis via induction of proapoptotic WTp53 target BAX and PUMA genes in vitro. Mouse xenograft studies showed suppression of tumors induce

SUBMITTER: Hwang E 

PROVIDER: S-EPMC11477845 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature