Elevated Circulating Levels of Gut Microbe-Derived Trimethylamine <i>N</i>-Oxide Are Associated with Systemic Sclerosis.

ABSTRACT: Background/Objectives: Alterations in fecal microbial communities in patients with systemic sclerosis (SSc) are common, but the clinical significance of this observation is poorly understood. Gut microbial production of trimethylamine (TMA), and its conversion by the host to trimethylamine N-oxide (TMAO), has clinical and mechanistic links to cardiovascular and renal diseases. Direct provision of TMAO has been shown to promote fibrosis and vascular injury, hallmarks of SSc. We sought to determine levels of TMAO and related metabolites in SSc patients and investigate associations between the metabolite levels with disease features. Methods: This is an observational case:control study. Adults with SSc (n = 200) and non-SSc controls (n = 400) were matched fo

SUBMITTER: Ho KJ 

PROVIDER: S-EPMC11477889 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature