Rapid Concentration of Ga-68 and Proof-of-Concept Microscale Labeling of [⁶⁸Ga]Ga-PSMA-11 in a Droplet Reactor.

ABSTRACT: The radiometal gallium-68 (Ga-68) has garnered significant interest due to its convenient production via compact and widely available generators and the high performance of ⁶⁸Ga-labeled compounds for positron-emission tomography (PET) imaging for cancer diagnosis and management of patients undergoing targeted radionuclide therapy. Given the short half life of Ga-68 (68 min), microfluidic-based radiosynthesis is a promising avenue to establish very rapid, efficient, and routine radiolabeling with Ga-68; however, the typical elution volume of Ga-68 from a generator (4-10 mL) is incompatible with the microliter reaction volumes of microfluidic devices. To bridge this gap, we developed a microscale cartridge-based approach to concentrate Ga-68. By optimizing cartridge design, resin

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11477945 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature