Relaxivity Modulation of Gd-HPDO3A-like Complexes by Introducing Polar and Protic Peripheral Groups.

ABSTRACT: In the last three decades, high-relaxivity Magnetic Resonance Imaging (MRI) contrast agents (CAs) have been intensively sought, aiming at a reduction in the clinically injected dose while maintaining the safety of the CA and obtaining the same pathological information. Thus, four new Gd(III) complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) macrocyclic structure were designed and synthesized by introducing further polar and protic functional groups (amides, phosphonates, and diols) adjacent to the metal-coordinated hydroxyl group. A detailed ¹H NMR relaxometric analysis allowed us to investigate the effect of these functional groups on the relaxivity, which showed a 20-60% increase (at 0.5 T, 298 K, and pH 7.4) with re

SUBMITTER: Camorali S 

PROVIDER: S-EPMC11478047 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature