2D MXene Nanosheets with ROS Scavenging Ability Effectively Delay Osteoarthritis Progression.

ABSTRACT: MXenes nanosheets with high conductivity, hydrophilicity, and excellent reactive oxygen species (ROS) scavenging ability have shown promise in treating various degenerative diseases correlated with abnormal ROS accumulation. Herein, the therapeutic potential of Ti₃C₂T_x nanosheets, which is the most widely investigated MXene material, in delaying osteoarthritis (OA) progression is demonstrated. In vitro experiments indicate the strong ROS scavenging capacity of Ti₃C₂T_x nanosheets and their acceptable biocompatibility. Ti₃C₂T_x nanosheets effectively protect chondrocytes from cell death induced by oxidative stress. In addition, Ti₃C₂T_x nanosheets demonstrate a pr

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11478061 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature