Direct, Broad-Spectrum Antimicrobial Activity of Ag⁺-Doped Hydroxyapatite against Fastidious Anaerobic Periodontal and Aerobic Dental Bacteria.

ABSTRACT: Periodontitis and caries, while seemingly innocuous medical conditions, actually pose significant challenges because of their potential etiology with far more serious conditions. Efficacious treatment is hindered by bacterial antibiotic resistance. Standard AgNPs are ineffective against periodontal anaerobic bacteria, because they require oxidative dissolution to release Ag⁺ ions, which are the actual antimicrobial agents, but oxidation is not possible under anaerobic conditions. Prior studies on Ag-based periodontal antimicrobial materials either did not confirm a silver oxidation state or did not use strictly anaerobic growth media or both, causing spurious antimicrobial efficacy estimates. Here, we prove that silver ion-doped hydroxyapatite nanoparticles (AgHAp NPs) synthesiz

SUBMITTER: Hu R 

PROVIDER: S-EPMC11478222 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature