Quinoxaline 1,4-di-<i>N</i>-oxide Derivatives as New Antinocardial Agents.

ABSTRACT: Mycetoma is currently considered as a neglected tropical disease. The incidence of mycetoma is unknown but most of the worldwide cases are present in the "mycetoma belt" including countries like Mexico, India, Senegal, and others. The treatment of mycetoma depends on the etiological agent responsible for the case. Treatment success reaches 60 to 90%; however, common treatment has been reported to be ineffective in some cases, due in part to resistance to the prescribed antibiotics. Therefore, it is necessary to develop new therapeutic options. In the past two decades, quinoxaline derivatives have shown relevance as antibacterial agents. Therefore, in this work, esters of quinoxaline 1,4-di-N-oxide derivatives were evaluated in vitro against the reference strain CECT-3052 from N.

SUBMITTER: Palos I 

PROVIDER: S-EPMC11478375 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature