Association between Serum Zinc and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis: The Osaka Dialysis Complication Study (ODCS).

ABSTRACT:

Background/objectives

Zinc is an essential microelement, and its deficiency is common in patients undergoing hemodialysis. However, the association between serum zinc and mortality in these patients remains unclear. The aim of this study was to explore the possible association between serum zinc levels and all-cause mortality in prevalent patients with kidney failure on maintenance hemodialysis.

Methods

This was a prospective cohort study of maintenance hemodialysis patients followed up for 5 years. The key exposure was serum zinc level measured at baseline, and the outcome was all-cause mortality. Their association was analyzed using Cox proportional hazard models.

Results

Among 1662 eligible patients selected for this analysis, 468 (28%) died. Lower serum zinc level

SUBMITTER: Nakatani S 

PROVIDER: S-EPMC11478467 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature