Synergistic Effects of Korean Mistletoe and Apple Peel Extracts on Muscle Strength and Endurance.

ABSTRACT: Muscular strength and endurance are vital for physical fitness. While mistletoe extract has shown efficacy in significantly increasing muscle strength and endurance, its accessibility is limited. This study explores combining mistletoe and apple peel extracts as an effective muscle health supplement. Analyses of histology, RNA, and protein in the combined extract-treated mouse group demonstrated significant enhancements in muscle strength and endurance, evidenced by larger muscle fibers, improved mitochondrial function, and a higher ratio of type I and IIa muscle fibers. Combining half doses of each extract resulted in greater improvements than using each extract separately, indicating a synergistic effect. Pathway analysis suggests that the observed synergy arises from complementary mecha

SUBMITTER: Kang YG 

PROVIDER: S-EPMC11478607 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature