Prediabetes increases the risk of pancreatic cancer: A meta-analysis of longitudinal observational studies.

ABSTRACT:

Background

Glycemic disorder is closely related to the risk of pancreatic cancer, but previous studies focused on the influence of diabetes. The aim of this meta-analysis was to investigate the influence of prediabetes, an intermediate state between normoglycemia and diabetes, on the risk of pancreatic cancer.

Methods

Relevant longitudinal observational studies were identified through a search of Medline, Embase, and Web of Science databases. To minimize the influence of between-study heterogeneity, a randomized-effects model was used to pool the results.

Results

Nine cohort studies including 26,444,624 subjects were available for the meta-analysis. Among them, 2,052,986 (7.8%) had prediabetes at baseline, and the participants were followed for a mean duration of 5.9

SUBMITTER: Huang X 

PROVIDER: S-EPMC11478827 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature