Orthosilicic acid inhibits human osteoclast differentiation and bone resorption.

ABSTRACT:

Context

Silicon (Si), which is present in the diet in the bioavailable form of orthosilicic acid (OSA) and is detected as a dissolution product of certain bone-substitute materials, is suggested to promote bone health, and enhance bone healing, respectively. Silicon has been shown to stimulate osteoblastic cell differentiation and function, although the effect of Si on human osteoclasts is unclear.

Aim

The present study investigated the direct effects of Si on human osteoclast differentiation, gene expression, and bone resorption.

Material & methods

Human CD14+ monocytes were isolated from buffy coats and cultured with M-CSF and RANKL in medium without or with Si (50 μg/ml; constituting 75% OSA). The effects of Si on osteoclast differentiation were evaluated by TRAP-s

SUBMITTER: Magnusson C 

PROVIDER: S-EPMC11478830 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature