Dual-Responsive Alginate/PNIPAM Microspheres Fabricated by Microemulsion-Based Electrospray.

ABSTRACT: Smart materials for drug delivery are designed to offer a precise and controlled release of therapeutic agents. By responding to specific physiological stimuli, such as changes in temperature and pH, these materials improve treatment efficacy and minimize side effects, paving the way for personalized therapeutic solutions. In this study, we present the fabrication of dual-responsive alginate/poly(N-isopropylacrylamide) (PNIPAM) microspheres, having the ability to respond to both pH and temperature variations and embedding the lipophilic bioactive compound Ozoile. Ozoile^® Stable Ozonides is obtained from extra virgin olive oil and acts as an inducer, interacting with major biological pathways by means of modulating the systemic redox balance. The dual-responsive microspheres are

SUBMITTER: Ciarleglio G 

PROVIDER: S-EPMC11478996 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature