Enhanced Synthesis of Poly(1,4-butanediol itaconate) via Box-Behnken Design Optimization.

ABSTRACT: At present, there are too few organ and tissue donors. Due to the needs of the medical market, scientists are seeking new solutions. Those can be found in tissue engineering by synthesizing synthetic cell scaffolds. We have decided to synthesize a potential UV-crosslinked bio-ink for 3D printing, poly(1,4-butanediol itaconate), in response to emerging needs. Diol polyesters are commonly investigated for their use in tissue engineering. However, itaconic acid makes it possible to post-modify the obtained polymer via UV-crosslinking. This work aims to optimize the synthesis of poly(1,4-butanediol itaconate) in the presence of a catalyst, zinc acetate, without using any toxic reactant. The experiments used itaconic acid and 1,4-butanediol using the Box-Behnken mathematical planning method. Th

SUBMITTER: Mietus M 

PROVIDER: S-EPMC11479127 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature