The diagnostic value of metagenomic next-generation sequencing in critically ill patients with sepsis: A retrospective cohort study.

ABSTRACT: Metagenomic next-generation sequencing (mNGS) is a new high-throughput sequencing method that may have great importance in early diagnosis and clinical management of sepsis. This study aimed to detect the difference between mNGS and comprehensive routine microbiological test (CMT), and to explore the diagnostic efficacy of mNGS in septic patients. This study retrospectively analyzed 150 sepsis patients who were admitted to the intensive care units of 4 hospitals in Southwest China from October 1, 2018, to October 1, 2021, and underwent both blood mNGS and CMT. The demographic and clinical characteristics of the patients were recorded, and the distribution of pathogens was analyzed. Additionally, the diagnostic performance and concordance between mNGS and CMT were compared to evaluate the e

SUBMITTER: Li C 

PROVIDER: S-EPMC11479415 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature