The causal effects of inflammatory bowel disease on skin carcinoma: A two-sample Mendelian randomization study.

ABSTRACT: Observational studies have indicated that inflammatory bowel disease (IBD) patients have higher incidence of skin carcinoma (SC), including melanoma skin carcinoma (MSC) and nonmelanoma skin carcinoma (NMSC) than healthy people. However, whether there is a causal relationship between the 2 is unclear. The purpose of this study was to evaluate the causality of IBD on SC using the Mendelian randomization (MR) analysis. We performed a two-sample MR analysis using publicly available genome-wide association study data. Eligible instrumental variables were selected based on the 3 core assumptions of MR analysis. The inverse-variance weighted (IVW) approach served as the primary analytical method. Supplementary analyses were conducted using MR-Egger regression, the weighted median, the weighted m

SUBMITTER: Luo L 

PROVIDER: S-EPMC11479435 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature