A novel intracoronary hypothermia device reduces myocardial reperfusion injury in pigs.

ABSTRACT:

Background

Hypothermia therapy has been suggested to attenuate myocardial necrosis; however, the clinical implementation as a valid therapeutic strategy has failed, and new approaches are needed to translate into clinical applications. This study aimed to assess the feasibility, safety, and efficacy of a novel selective intracoronary hypothermia (SICH) device in mitigating myocardial reperfusion injury.

Methods

This study comprised two phases. The first phase of the SICH was performed in a normal porcine model for 30 minutes ( n = 5) to evaluate its feasibility. The second phase was conducted in a porcine myocardial infarction (MI) model of myocardial ischemia/reperfusion which was performed by balloon occlusion of the left anterior descending coronary artery for 60 minutes

SUBMITTER: Pei Z 

PROVIDER: S-EPMC11479452 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature