Exploring causal correlations between inflammatory cytokines and coronary heart disease: A Mendelian randomization study.

ABSTRACT: Coronary heart disease (CHD) is a global health concern, with inflammation significantly contributing to its pathogenesis. It is crucial to understand the relationship between inflammatory cytokines and CHD. This study investigates the causal correlations between circulating inflammatory cytokines and CHD using Mendelian randomization (MR), assessing both causative and resultant roles of these cytokines in CHD. In this bidirectional MR analysis, we used genetic data from a genome-wide association study (GWAS) of 60,801 CHD cases and 123,504 controls of European ancestry. We derived inflammatory cytokine data from a GWAS summary of 14,824 participants. The primary analytical approach was the inverse variance-weighted (IVW) method, supported by MR-Egger, weighted median, and weighted mode an

SUBMITTER: Lv L 

PROVIDER: S-EPMC11479489 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature