Diagnosis of schizophrenia by integrated saccade scores and associations with psychiatric symptoms, and functioning.

ABSTRACT: Eye movement as a neurobiological biomarker of schizophrenia. We aim to estimate diagnostic accuracy of integrated pro/antisaccade eye movement measurements to discriminate between healthy individuals and schizophrenic patients. We compared the eye movement performance of 85 healthy individuals and 116 schizophrenia-stable patients during prosaccade and antisaccade tasks. The difference eye movement measurements were accumulated by stepwise discriminant analysis to produce an integrated score. Finally, the diagnostic value of the integrated score was calculated by the receiver operating characteristic (ROC) area under the curve (AUC), and the best sensitivity and specificity were calculated based on the given cutoff values. Using discriminant analysis, an integrated score included the resi

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11479490 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature