Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.

ABSTRACT:

Background

Gastric cancer (GC), a malignant tumor with poor prognosis, is one of the leading causes of cancer-related deaths worldwide; consequently, identifying novel therapeutic targets is crucial for its corresponding treatment. NUF2 , a component of the NDC80 kinetochore complex, promotes cancer progression in multiple malignancies. Therefore, this study aimed to explore the potential of NUF2 as a therapeutic target to inhibit GC progression.

Methods

Clinical samples were obtained from patients who underwent radical resection of GC at Lanzhou University Second Hospital from 2016 to 2021. Cell count assays, colony formation assays, and cell-derived xenotransplantation (CDX) models were used to determine the effects of NUF2 on GC progression. Flow cytometry was used to det

SUBMITTER: Long B 

PROVIDER: S-EPMC11479523 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature