Disparate trajectories of cognitive aging among American Indian and Alaskan Native people with and without HIV.

ABSTRACT:

Objective

This study describes trajectories of cognitive aging among American Indian/Alaskan Native (AI/AN) adults with and without HIV and the role of immunosenescence longitudinally.

Method

We characterized trajectories of cognitive aging in a sample of 333 AI/AN and 309 non-Hispanic White (NHW) adults who were followed longitudinally for up to 20 years by the HIV Neurobehavioral Research Program (HNRP) across six U.S. research sites. We used growth curve modeling with autoregressive Lag-1 structures and heterogeneous residual variances to assess the role of ethnoracial identity and HIV grouping upon decline in trajectories of cognitive aging.

Results

HIV- AI/AN adults demonstrated earlier and steeper decline in normative trajectories of cognitive aging on tasks of

SUBMITTER: Savin MJ 

PROVIDER: S-EPMC11479638 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature