Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth.

ABSTRACT:

Background

Strong epidemiological evidence shows positive associations between exposure to per- and polyfluoroalkyl substances (PFAS) and adverse cardiometabolic outcomes (e.g., diabetes, hypertension, and dyslipidemia). However, the underlying cardiometabolic-relevant biological activities of PFAS in humans remain largely unclear.

Aim

We evaluated the associations of PFAS exposure with high-throughput proteomics in Hispanic youth.

Material and methods

We included 312 overweight/obese adolescents from the Study of Latino Adolescents at Risk (SOLAR) between 2001 and 2012, along with 137 young adults from the Metabolic and Asthma Incidence Research (Meta-AIR) between 2014 and 2018. Plasma PFAS (i.e., PFOS, PFOA, PFHxS, PFHpS, PFNA) were quantified using liquid-chromatog

SUBMITTER: Chen JC 

PROVIDER: S-EPMC11479670 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature