The genetic causal effect of hand grip strength on osteoporosis and falling risk: a Mendelian randomization study.

ABSTRACT:

Background

Patients with osteoporosis (OP) are often associated with decreased hand grip strength and increased risk of falling. It remains unclear whether there is a genetic causal between hand grip strength and OP, falling risk.

Methods

The Mendelian randomization study was used to investigate the genetic causal effect of low hand grip strength on total body bone mineral density (BMD) at different ages, OP, and falling risk. Genes for low hand grip strength, total body BMD at different ages, OP, and falling risk were obtained from published genome-wide association studies. Inverse variance weighted, MR-Egger, and weighted median were applied to perform the MR analysis. The Cochran's Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis were use

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11479888 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature