IL-33-primed human mast cells drive IL-9 production by CD4⁺ effector T cells in an OX40L-dependent manner.

ABSTRACT: Interleukin-33 (IL-33) is an alarmin released by epithelial cells in response to tissue damage. It activates resident immune sentinel cells, which then produce signals commonly associated with type 2 immune responses, particularly affecting infiltrating antigen-specific T cells. Given that mast cells (MCs) are a primary target of IL-33 and can shape T helper (Th) cell responses, we investigated the effect of IL-33 priming on the ability of MCs to influence Th cell cytokine production. To examine the Th cell/MC interaction, we developed human primary MC/memory CD4⁺ T-cell coculture systems involving both cognate and non-cognate interactions. Our results demonstrated that IL-33-primed MCs, whether as bystander cells cocultured with activated effector T cells or functioning as anti

SUBMITTER: Battut L 

PROVIDER: S-EPMC11479898 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature