Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma.

ABSTRACT:

Background

Hypoxic conditions in glioma are linked to tumor aggressiveness, poor prognosis, and treatment resistance. Long non-coding RNAs (lncRNAs) play key roles in the hypoxic and immune microenvironment of cancers, but their link to hypoxia-induced immunosuppression in high-grade glioma (HGG) is not well-studied.

Methods

Gene expression profiles from TCGA and CGGA, along with clinical and genomic data, were analyzed. Bioinformatics methods including Consensus Clustering, Pearson correlation, and Cox regression analyses were used. Cell proliferation was assessed using cell counting kit-8 and colony formation assays. Glioma-macrophage interactions were evaluated using a co-culture model.

Results

Hypoxia subtype clustering showed hypoxic stress correlates with worse

SUBMITTER: Li X 

PROVIDER: S-EPMC11479907 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature