Genetic variants of <i>LRRC8C</i>, <i>OAS2</i>, and <i>CCL25</i> in the T cell exhaustion-related genes are associated with non-small cell lung cancer survival.

ABSTRACT:

Background

T cell exhaustion is a state in which T cells become dysfunctional and is associated with a decreased efficacy of immune checkpoint inhibitors. Lung cancer has the highest mortality among all cancers. However, the roles of genetic variants of the T cell exhaustion-related genes in the prognosis of non-small cell lung cancer (NSCLC) patients has not been reported.

Methods

We conducted a two-stage multivariable Cox proportional hazards regression analysis with two previous genome-wide association study (GWAS) datasets to explore associations between genetic variants in the T cell exhaustion-related genes and survival of NSCLC patients. We also performed expression quantitative trait loci analysis for functional validation of the identified variants.

Results

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SUBMITTER: Lu G 

PROVIDER: S-EPMC11479925 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature