Genetically predicted 486 blood metabolites in relation to risk of esophageal cancer: a Mendelian randomization study.

ABSTRACT:

Background and objective

Enhancing therapy choices for varying stages of esophageal cancer and improving patient survival depend on timely and precise diagnosis. Blood metabolites may play a role in either causing or preventing esophageal cancer, but further research is needed to determine whether blood metabolites constitute a genetic risk factor for the disease. In order to tackle these problems, we evaluated the causal association between esophageal cancer and 486 blood metabolites that functioned as genetic proxies using a two-sample Mendelian randomization (MR) study.

Methods

We utilized two-sample MR analyses to evaluate the causal links between blood metabolites and esophageal cancer. For the exposure, we used a genome-wide association study (GWAS) of 486 metabolites,

SUBMITTER: Jia C 

PROVIDER: S-EPMC11479936 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature