Exploration of first onsets of mania, schizophrenia spectrum disorders and major depressive disorder in perimenopause.

ABSTRACT: Although the relationship between perimenopause and changes in mood has been well established, knowledge of risk of a broad spectrum of psychiatric disorders associated with reproductive aging is limited. Here we investigate whether the perimenopause (that is, the years around the final menstrual period (FMP)) is associated with increased risk of developing psychiatric disorders compared with the late reproductive stage. Information on menopausal timing and psychiatric history was obtained from nurse-administered interviews and online questionnaires from 128,294 female participants within UK Biobank. Incidence rates of psychiatric disorders during the perimenopause (4 years surrounding the FMP) were compared with the reference premenopausal period (6-10 years before the FMP). The rates wer

SUBMITTER: Shitomi-Jones LM 

PROVIDER: S-EPMC11479941 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature