Paralysis caused by dinotefuran at environmental concentration via interfering the Ca²⁺-ROS-mitochondria pathway in <i>Chironomus kiiensis</i>.

ABSTRACT:

Introduction

Dinotefuran as the third-generation of neonicotinoid insecticides is extensively used in agriculture worldwide, posing a potential toxic threat to non-target animals and humans. However, the chronic toxicity mechanism related to mitochondria damage of dinotefuran to non-target animals at environmental concentration is unclear.

Methods

In this study, the mitochondria damage and oxidative stress of dinotefuran on Chironomus kiiensis were investigated at environmental concentrations by long-term exposure. At the same time, relevant gene expressions of these toxicity indexes were measured as sensitive ecotoxicity biomarkers to reflect the toxic effects of dinotefuran on Chironomidae.

Results

Our present study showed that chronic exposure to environment

SUBMITTER: Wei F 

PROVIDER: S-EPMC11479960 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature