Plasma proteomics and carotid intima-media thickness in the UK biobank cohort.

ABSTRACT:

Background and aims

Ultrasound derived carotid intima-media thickness (cIMT) is valuable for cardiovascular risk stratification. We assessed the relative importance of traditional atherosclerosis risk factors and plasma proteins in predicting cIMT measured nearly a decade later.

Method

We examined 6,136 UK Biobank participants with 1,461 proteins profiled using the proximity extension assay applied to their baseline blood draw who subsequently underwent a cIMT measurement. We implemented linear regression, stepwise Akaike Information Criterion-based, and the least absolute shrinkage and selection operator (LASSO) models to identify potential proteomic as well as non-proteomic predictors. We evaluated our model performance using the proportion variance explained (R

SUBMITTER: Chen ML 

PROVIDER: S-EPMC11480011 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature