A scoping review of preclinical intensive care unit-acquired weakness models.

ABSTRACT:

Background

Animal models focusing on neuromuscular outcomes are crucial for understanding the mechanisms of intensive care unit-acquired weakness (ICU-AW) and exploring potential innovative prevention and treatment strategies.

Aim

To analyse and evaluate preclinical ICU-AW models.

Methods

We manually searched five English and four Chinese databases from 1 January 2002, to 1 February 2024, and reviewed related study references. Full-text publications describing animal models of muscle weakness and atrophy in critical illness were included. Detailed information about model types, animal species, sex, age, induction methods, outcome measures, drawbacks and strengths was extracted from each included study.

Results

A total of 3,451 citations were initially retrieved

SUBMITTER: Yu Q 

PROVIDER: S-EPMC11480018 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature