Associations Between Mental Disorders in Donors and Matched Recipients of Hematopoietic Stem Cell Transplants: A Population-Based Cohort Study.

ABSTRACT:

Background

Immunological mechanisms have been implicated in the development of mental disorders, and interestingly, case reports have suggested that hematopoietic stem cell transplantation (HSCT) can both transmit and cure psychotic disorders by replacing immune progenitor cells.

Methods

Using Danish registers, we followed patients who received HSCT from donors with a psychiatric diagnosis or psychotropic medication use. We assessed risk of incident mental disorders or psychotropic medication use compared with recipients with unaffected donors. We identified 464 donor-recipient pairs (51.3% male recipients). All donor-recipient pairs were related.

Results

Receiving HSCT from a donor with a psychiatric history was not significantly associated with incident psychiatric

SUBMITTER: Romer TB 

PROVIDER: S-EPMC11480220 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature