Antimicrobial and antibiotic-potentiating effect of calcium peroxide nanoparticles on oral bacterial biofilms.

ABSTRACT: Bacterial biofilms represent a prominent biological barrier against physical and chemical attacks. Disturbing the anaerobic microenvironment within biofilms by co-delivery of oxygen appears as a promising strategy to enhance the activity of an antibiotic. Here, we report the effect of oxygen-producing calcium peroxide nanoparticles (CaO₂ NP) in combination with tobramycin sulfate (Tob). On Pseudomonas aeruginosa PAO1 biofilms in vitro, the additive effect of CaO₂ NP towards Tob activity enhanced biofilm eradication by 2 log compared to Tob alone. For natural biofilms grown in the oral cavity of human volunteers in situ, treatment by CaO₂ NP alone slightly increased the fraction of dead bacteria from 44% in various controls, including Tob alone, to 57%. Howe

SUBMITTER: Bankar N 

PROVIDER: S-EPMC11480382 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature