Mitophagy related diagnostic biomarkers for coronary in-stent restenosis identified using machine learning and bioinformatics.

ABSTRACT: Percutaneous coronary intervention (PCI) combined with stent implantation is currently one of the most effective treatments for coronary artery disease (CAD). However, in-stent restenosis (ISR) significantly compromises its long-term efficacy. Mitophagy plays a crucial role in vascular homeostasis, yet its role in ISR remains unclear. This study aims to identify mitophagy-related biomarkers for ISR and explore their underlying molecular mechanisms. Through differential gene expression analysis between ISR and Control samples in the combined dataset, 169 differentially expressed genes (DEGs) were identified. Twenty-three differentially expressed mitophagy-related genes (DEMRGs) were identified by intersecting with mitophagy-related genes (MRGs) from the GeneCards, and functional enrichment

SUBMITTER: Shen M 

PROVIDER: S-EPMC11480419 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature