TGF-β-mediated crosstalk between TIGIT⁺ Tregs and CD226⁺CD8⁺ T cells in the progression and remission of type 1 diabetes.

ABSTRACT: Type 1 diabetes (T1D) is a chronic autoimmune condition characterized by hyperglycemia resulting from the destruction of insulin-producing β-cells that is traditionally deemed irreversible, but partial remission (PR) with temporary reversal of hyperglycemia is sometimes observed. Here we use single-cell RNA sequencing to delineate the immune cell landscape across patients in different T1D stages. Together with cohort validation and functional assays, we observe dynamic changes in TIGIT⁺CCR7^- Tregs and CD226⁺CCR7^-CD8⁺ cytotoxic T cells during the peri-remission phase. Machine learning algorithms further identify TIGIT⁺CCR7^- Tregs and CD226⁺CD8⁺ T cells as biomarkers for β-cell function decline

SUBMITTER: Zhong T 

PROVIDER: S-EPMC11480485 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature