Concurrent and longitudinal neurostructural correlates of irritability in children.

ABSTRACT: Irritability, or an increased proneness to frustration and anger, is common in youth; however, few studies have examined neurostructural correlates of irritability in children. The purpose of the current study was to examine concurrent and longitudinal associations between brain structure and irritability in a large sample of 9-10-year-old children. Participants included 10,647 children from the Adolescent Brain Cognitive Development^sm Study (ABCD Study^®). We related a latent irritability factor to gray matter volume, cortical thickness, and surface area in 68 cortical regions and to gray matter volume in 19 subcortical regions using structural equation modeling. Multiple comparisons were adjusted for using the false discovery rate (FDR). After controlling for age, se

SUBMITTER: Archer C 

PROVIDER: S-EPMC11480493 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature