Vitamin B₁₂ protects necrosis of acinar cells in pancreatic tissues with acute pancreatitis.

ABSTRACT: Pharmacological agents regarding the most optimal treatments of acute pancreatitis remain. One-carbon metabolism nutrients as therapeutic agents in many diseases might be involved in acute pancreatitis. The roles are acquired exploration in acute pancreatitis. We utilized Mendelian randomization to assess the causal impact of folate, homocysteine, and vitamin B₁₂ (VB₁₂) on acute pancreatitis. Wild-type and corresponding genetically modified mouse models were used to verify the genetic correlating findings. A negative association between genetically predicted serum VB₁₂ levels and risks of acute pancreatitis was identified in human population. The transcobalamin receptor (TCblR)/CD320 gene ablation that decreased cellular VB₁₂ uptake and AT

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11480517 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature