IL-15-induced CD38⁺HLA-DR⁺CD8⁺ T cells correlate with liver injury via NKG2D in chronic hepatitis B cirrhosis.

ABSTRACT:

Objectives

CD8⁺ T cells play a critical role in the immune dysfunction associated with liver cirrhosis. CD38⁺HLA-DR⁺CD8⁺ T cells, or bystander-activated CD8⁺ T cells, are involved in tissue injury but their specific contribution to liver cirrhosis remains unclear. This study sought to identify the mechanism for CD38⁺HLA-DR⁺CD8⁺ T cell-mediated pathogenesis during liver cirrhosis.

Methods

The immunophenotype, antigen specificity, cytokine secretion and cytotoxicity-related indicators of CD38⁺HLA-DR⁺CD8⁺ T cells were determined using flow cytometry. The functional properties of these cells were assessed using transcriptome analysis. CD38⁺HLA-DR

SUBMITTER: Fan J 

PROVIDER: S-EPMC11480635 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature